Expression of PCNA and LNGFr in olfactory epithelium of patients suffering from dysosmia caused by chronic sinusitis.
- Author:
Li LI
1
;
Yan ZHANG
;
Jianzhang PU
;
Guifang LI
;
Ming YE
Author Information
1. Department of Otolaryngology, Beijing Shunyi Hospital, Beijing, 101300, China.
- Publication Type:Journal Article
- MeSH:
Chronic Disease;
Humans;
Immunohistochemistry;
Nerve Tissue Proteins;
metabolism;
Olfaction Disorders;
metabolism;
Olfactory Mucosa;
metabolism;
Proliferating Cell Nuclear Antigen;
metabolism;
Receptors, Nerve Growth Factor;
metabolism;
Sinusitis;
complications
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(11):502-506
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of PCNA and LNGFr in olfactory epithelium of patients suffering from dysosmia caused by chronic sinusitis, and the function of LNGFr.
METHOD:Forty-six patients undergoing FESS were chosen. Before operation, their olfactory functions were examined with CCCRC. According to their CCCRC scores, they were divided into three groups. Group A: Patients with chronic sinusitis and dysosmia 25 cases; Group B: Patients with chronic sinusitis and a normal olfactory function 10 cases; Group C: Patients with deviation of nasal septum and a normal olfactory function 11 cases. The expressions of PCNA and LNGFr were measured in olfactory mucosas of the three groups by immunohistochemistry.
RESULT:In basal cells, the expression of PCNA and LNGFr in group A was higher than that in group B (P < 0.01). and in group C (P < 0.01). There was negative correlation between positive cells of PCNA and CCCRC score in basal cells of group A (r = -0.7441, P < 0.01); There was negative correlation between integral optical density of LNGFr and CCCRC score in basal cells of group A (r = -0.4407, P < 0.05). There was positive correlation between positive cells of PCNA and integral optical density of LNGFr in basal cells of group A (r = 0.5317, P < 0.01).
CONCLUSION:Basal cells proliferated dramatically in patients suffering from dysosmia caused by chronic sinusitis. The proliferating capacity of basal cells was related to up-regulation of LNGFr expression.
