Animal model of obstructive sleep apnea with New Zealand rabbit.
- Author:
Weiqing WANG
1
;
Jiande HE
;
Xiaofeng LU
Author Information
1. Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Research Institute of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Apnea;
chemically induced;
physiopathology;
Disease Models, Animal;
Oxygen;
metabolism;
Rabbits;
Sleep Apnea, Obstructive;
chemically induced;
physiopathology;
Snoring;
physiopathology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2012;26(12):555-557
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To build up a steady and credible animal model on obstructive sleep apnea-hypopnea syndrome (OSAHS) with New Zealand rabbit.
METHOD:Ten New Zealand rabbit were divided into two groups (A and B, 5 for each). Group A was treated by injecting Dimethiconum from exterior. Group B was blank. EEG, snoring and oxygen-saturation were recorded by PSG after operation. Examination was repeated two weeks later and one month later. CT was done in the operation and two weeks later. Animals were sacrificed three months later and the Dimethiconum in the body was used for examination with light microscopy.
RESULT:Group A showed apnea or hypopnea and decreasing SaO2 after operation. The changes in group A were more obvious at two weeks and one month.
CONCLUSION:A steady and credible animal model of OSAHS has been built. The model provides a tool to study the pathogenesy and pathophysiology of OSAHS.
