Successful Immunosuppression with Cyclosporine after Renal Transplantation in a Patient with Chronic Renal Failure Due to Postpartum Hemolytic Uremic Syndrome.
- Author:
Jeoung Hwa KIM
1
;
Min Ho HWANG
;
Min Seob SONG
;
Chan Ho YOON
;
Yong Moon KIM
;
Kwang Young LEE
;
Sung Gil PARK
Author Information
1. Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea. moonc@hosp.sch.ac.kr
- Publication Type:Case Report
- Keywords:
Postpartum hemolytic uremic syndrome;
Cyclosporine;
Renal transplantation
- MeSH:
Anemia, Hemolytic;
Creatinine;
Cyclosporine*;
Dialysis;
Hemolytic-Uremic Syndrome*;
Humans;
Immunosuppression*;
Incidence;
Kidney Failure, Chronic*;
Kidney Transplantation*;
Plasma Exchange;
Postpartum Period*;
Prednisolone;
Pregnancy;
Renal Insufficiency;
Risk Factors;
Thrombocytopenia;
Transplantation;
Transplants
- From:The Journal of the Korean Society for Transplantation
2001;15(1):106-109
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hemolytic uremic syndrome is characterized by the symptoms of microangiopathic hemolytic anemia, thrombocytopenia and renal failure. The incidence of hemolytic uremic syndrome associated with pregnancy is 10 to 25 percent. Hemolytic uremic syndrome is treated with adjunctive therapies, such as anti-platelet agents, glucocorticoid and plasma exchange. However, many patients experience a residual impairment in renal function and some of them progress to end-stage renal disease requiring dialysis or renal transplantation. Immunosuppression with cyclosporine has been implicated as a significant risk factor for post- transplant hemolytic uremic syndrome. A number of reports on transplant recipients have recognized cyclosporine-induced hemolytic uremic syndrome as a distinct entity and a potentially serious complication of cyclosporine administration.We report a case of a patient with successful renal transplantation using cyclosporine who had a severe case of post-partum hemolytic uremic syndrome that progressed to end-stage renal disease. After cadaver-donor renal transplantation using cyclosporine, mycophenolate mofetil and prednisolone her graft function at two years is normal with serum creatinine 1.0 mg/dl.
