Polymorphisms of GSTM1, GSTT1 and susceptibility of laryngeal and hypopharyngeal carcinomas.
- Author:
Qin LI
1
;
Lingrong WANG
;
Yanlin CHEN
;
Yinghua DU
;
Ping KONG
;
Yufen LI
;
Xiaoqun XU
Author Information
1. Department of Otorhinolaryngology, Linyi People's Hospital of Shandong, Linyi, 276003, China. liqin8226@163.com
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
genetics;
Case-Control Studies;
Disease Susceptibility;
Female;
Gene Frequency;
Genotype;
Glutathione Transferase;
genetics;
Humans;
Hypopharyngeal Neoplasms;
genetics;
Laryngeal Neoplasms;
genetics;
Male;
Polymorphism, Genetic
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(24):1105-1111
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the relationship between genetic polymorphisms of GSTM1 GSTT1 and the susceptibility of laryngeal and hypopharyngeal carcinomas (LHC).
METHOD:The GSTM1 and GSTT1 genotypes were determined by multiplex PCR analysis in 76 LHC patients and 76 population controls. The association between the genotypes and LHC risk was measured by odds ratios (ORs) and 95% confidence intervals (95% CIs).
RESULT:The frequency of GSTM1 null genotype was 59.2% in the LHC patients and 42.1% in controls (OR=1.935, 95% CI=1.069-3.510), the difference was significant (P<0.01). The frequency of GSTT1 null genotype was 57.9% in the LHC patients and 51.3% in controls. The difference was not significant (P>0.05). In smokers, the risk of the LHC increased in subjects of GSTM1 null genotype (OR=5.545, 95% CI=2.158-13.528).
CONCLUSION:GSTM1 polymorphisms are associated with susceptibility to the LHC. It has the synergistic effects with smoking in the development of the LHC. GSTT1 genotypes might have no association with risk of the LHC in urban Linyi.
