A Case of Atypical Generalized Zoster with Suspicious Esophageal Involvement and Early Relapse in an Adult Renal Transplant Recipient.
- Author:
Kook Hwan OH
1
;
Se Joong KIM
;
Seong Gyun KIM
;
Hyun Lee KIM
;
Eui Chong KIM
;
Myoung Don OH
;
Yon Su KIM
;
Cu Rie AHN
;
Jin Suk HAN
;
Myoung Hee PARK
;
Suhng Gwon KIM
;
Jung Sang LEE
;
Sang Joon KIM
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Atypical generalized;
Zoster;
Renal transplantation;
Esophagus;
Early relapse
- MeSH:
Acyclovir;
Adult*;
Cyclosporine;
Enzyme-Linked Immunosorbent Assay;
Esophagus;
Herpes Zoster*;
Humans;
Immunocompromised Host;
Immunoglobulin G;
Immunoglobulin M;
Kidney Transplantation;
Male;
Pharynx;
Polymerase Chain Reaction;
Recurrence*;
Skin;
Transplantation*;
Ulcer
- From:The Journal of the Korean Society for Transplantation
2001;15(1):110-113
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
An adult case of atypical generalized zoster six years after renal transplantation in a 30-year-old male is reported. He had generalized skin lesions and esophageal ulcers from the pharynx to the mid-esophagus. Serum ELISA tests for VZV antibody were positive for both IgM and IgG. Polymerase chain reaction for VZV-specific gene fragment was positive from the secretion of the cutaneous vesicles. Pre-transplantation work- up for serum IgG test for VZV showed a positive result seven years ago. He had been taking triple immunosuppressive drugs including cyclosporin A, deflazacort and mycophenolate mofetil. The skin lesions and esophageal ulcers improved substantially after high dose parenteral acyclovir therapy. He had a relapse of localized grouped vesicles 16 days later but the lesion improved after oral anti- viral therapy. In this case, suspicious esophageal, as well as disseminated cutaneous, involvement of VZV infection in an immunocompromised patient and its early relapse after recovery are unusual.
