Expression of toll-like receptors signaling pathway in chronic rhinosinusitis with nasal polyps.
- Author:
Xin WANG
1
;
Chunyuan ZHAO
;
Ming LIU
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, Second Hospital Affiliated to Harbin Medical Universitry, Harbin,150086, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Case-Control Studies;
Child;
Chronic Disease;
Female;
Humans;
Male;
Middle Aged;
Nasal Mucosa;
metabolism;
Nasal Polyps;
genetics;
metabolism;
Oligonucleotide Array Sequence Analysis;
RNA, Messenger;
genetics;
Signal Transduction;
Sinusitis;
genetics;
metabolism;
Toll-Like Receptors;
genetics;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(23):1059-1062
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of Toll-like receptors (TLRs) signaling pathway in chronic rhinosinusitis (CRS) with nasal polyps.
METHOD:Gene microarray analysis was used to detect the expression of TLRs signaling pathway in CRS with nasal polyps.
RESULT:Of 19 differentially expressed (two fold changes), 4 genes were upregulated and 15 genes were downregulated.
CONCLUSION:The differentially expressed genes in TLRs signaling pathway may exert its effect in the pathogenesis of CRS. In addition, the roles of TLR9 and its agonists need further study.
