Treatment and clinical analysis of laryngeal function preserving surgery in hypopharyngeal carcinoma.
- Author:
Jiaxi LI
1
;
Xingru LI
;
Gao SUN
;
Bo QU
;
Hui WANG
;
Zhixiang GUO
Author Information
1. Department of Otorhinolaryngology, the 463rd Hospital of PLA, Shenyang, 110042, China. lijiaxi463@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Carcinoma, Squamous Cell;
surgery;
Female;
Humans;
Hypopharyngeal Neoplasms;
surgery;
Laryngeal Neoplasms;
surgery;
Laryngectomy;
methods;
Larynx;
physiology;
surgery;
Male;
Middle Aged;
Pharyngectomy;
methods;
Retrospective Studies
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(21):973-977
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the therapeutic effect and the prognosis of the laryngeal function preserving surgery (LFPS) and total laryngectomy in hypopharyngeal carcinoma.
METHOD:Ninety-three cases of laryngopharynx carcinoma were retrospectively analyzed from September 1974 to September 2006. Among which 57 cases were primary pyriform sinus cancer, 20 cases were postero-cricoid cancer and 16 cases were postero-pharyngeal wall cancer. 53 cases were treated by LFPS, and 40 cases were treated by total laryngectomy. The treatment effectiveness, complication, survival rate and repair materials were analysed.
RESULT:Adopting Kaplan-Meier survival analysis, the 3-year survival rates were 69.9% and 5-year survival rates were 43.0%. The 3-year survival rates of LFPS and Non-LFPS were 73.6% and 67.5%, and the 5-year survival rates of LFPS and Non-LFPS were 49.1% and 32. 5%. There was no significant difference between the two groups (chi2 = 2.566, P > 0.05). Single element analysis indicated survival rates concerned with T-stage (chi2 = 9.764, P < 0.05), neck lymphatic transfer (chi2 = 10.472, P < 0.01) and the degree of pathological differentiation (chi2 = 25.894, P < 0.01). Cox regression analysis suggested that T-stage, the degree of pathological differentiation and whether going through the surgical operation were the independent element of the patient's prognosis. There was no significant difference between LFPS and No-LFPS in the neoplasms location, complication, neoplasms residuum and neoplasms recurrence.
CONCLUSION:LFPS did not affect the survival rates and LFPS was feasible. LFPS can increase the living quality of laryngopharynx carcinoma patients.
