Expression and clinical significance of Ang-2 and MMP-7 in laryngeal carcinoma.
- Author:
Gang QIN
1
;
Wenjun LIU
;
Ling YU
;
Zhuoping LIANG
;
Zuyao CHEN
;
Wanrong LI
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, China. qin-lzm@163.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Angiopoietin-2;
metabolism;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Matrix Metalloproteinase 7;
metabolism;
Middle Aged;
Neoplasm Staging;
Prognosis
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(21):978-981
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression and clinical significance of Ang-2 and MMP-7 protein in laryngeal carcinoma tissue.
METHOD:Immunohistochemical technique was used to detect the expression of Ang-2 and MMP-7 protein in 65 tissues of laryngeal carcinoma and 34 biopsies of adjacent non- cancerous tissue. The relationship between the expression of Ang-2 and MMP-7 and invasion, metastasis or prognosis in laryngeal carcinoma tissue was analyzed.
RESULT:The positive rates of Ang-2 and MMP-7 were significantly higher in laryngeal carcinoma tissue than those in adjacent non-cancerous tissue (P < 0.05). The level of Ang-2 and MMP-7 expression had no significant correlations with the age and course as well as the smoking, drinking, histological differentiation of carcinoma and clinical classification (P > 0.05). While the expression of Ang-2 significantly differed between patients with different T stage and clinical stage (P < 0.05), and the expression of MMP-7 was notably correlated with the T stage, clinical stage and lymph node metastases (P < 0.05). There was a correlation between the expression of Ang-2 and MMP-7 (P < 0.05). The Kaplan-Meier survival analysis showed that patients with positive expression of Ang-2 had worse overall survival (P < 0.05). However, MMP-7 expression was not related to overall survival or disease-free survival (all P > 0.05). Cox regression analysis indicated that Ang-2 and MMP-7 expression were independent prognostic factors of laryngeal carcinoma.
CONCLUSION:Overexpression of Ang-2 and MMP-7 was observed in laryngeal carcinoma and they might be served as an objective indicator for biological behaviour and prognosis.
