To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm by immunohistochemistry.
- Author:
Hongjun LIANG
1
;
Bin LIU
;
Wenyue JI
Author Information
1. Department of Otolaryngology, Shengjing Hospital, China Medical University, Shenyang, 110004, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Cyclin D1;
metabolism;
Female;
Humans;
Immunohistochemistry;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Middle Aged;
Neoplasm Staging;
STAT3 Transcription Factor;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(21):982-988
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm with immunohistochemistry method.
METHOD:With immunohistochemistry method, we investigated the expression of Stat3 and Cyclin D1 in laryngeal neoplasm and analysis the relationship between Stat3 and clinical pathological factor.
RESULT:Stat3 and Cyclin D1 overexpressed in laryngeal neoplasm tissue and they have positive relationship.
CONCLUSION:Active Stat3 may promote the transcription of target gene Cyclin D1, which could accelerate carcinomatous change.
