Expression of RAGE in laryngeal squamous cell carcinoma and clinical significance.
- Author:
Huiping ZHANG
1
;
Rong ZHANG
;
Hanjing SHANGGUAN
Author Information
1. Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Chin.
- Publication Type:Journal Article
- MeSH:
Aged;
Aged, 80 and over;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Lymphatic Metastasis;
Male;
Middle Aged;
Neoplasm Staging;
Receptor for Advanced Glycation End Products;
Receptors, Immunologic;
metabolism;
Reverse Transcriptase Polymerase Chain Reaction
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(21):985-988
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression and clinical significance of receptor for advanced glycation end products (RAGE) in laryngeal squamous cell carcinoma (LSCC).
METHOD:immunohistochemical staining was used to detect the expressions of RAGE protein and semiquantitative method of reverse transcriptase polymerase chain reaction (RT-PCR) was used to analyze the expression level of RAGE mRNA in LSCC tissues and laryngeal normal tissues of 37 cases, respectively.
RESULT:The mRNA and protein expression of RAGE was significantly higher in LSCC than that in normal laryngeal tissues (P < 0.05), correlated with differentiation (P < 0.01), but not with tumor stage and location (P > 0.05).
CONCLUSION:The expression levels of RAGE were significantly higher in LSCC than these in laryngeal normal tissues, RAGE is involved in differentiation of LSCC.
