Studies on inhibitive effect of low-voltage electrochemotherapy on head and neck cancer-bearing nude mice.
- Author:
Xuefeng WANG
1
Author Information
1. Department of Otorhinolaryngology, the First Affiliated Hospital, Liaoning Medical University, Jinzhou,121001, China. jzswang@126.com
- Publication Type:Journal Article
- MeSH:
Animals;
Antimetabolites, Antineoplastic;
administration & dosage;
therapeutic use;
Bleomycin;
administration & dosage;
therapeutic use;
Cell Line, Tumor;
Electrochemotherapy;
Female;
Head and Neck Neoplasms;
drug therapy;
therapy;
Humans;
Mice;
Mice, Inbred BALB C;
Mice, Nude;
Neoplasm Transplantation
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;23(21):991-994
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyse the therapie effect of low-voltage electrochemotherapy (EP) on the head and neck cancer.
METHOD:YCU-N861 human head and neck cancer cells were subcutaneously inoculated in the neck of nude mice to establish tumor-bearing models. Then the mice were treated with bleomycin (BLM, 20 microg per mouse), accompanied with electric stimulation (50 V or 100 V).
RESULT:BLM treatment applied with EP can significantly inhibit the proliferation of tumor cells than BLM or EP treatment separately (P < 0.01). The tumor volume, the mitotic index (MI) and the labeling index (LI) of Ki67 in BLM+EP group were all obviously decreased than BLM group, EP group and control group (P < 0.01).
CONCLUSION:Low-voltage electrochemotherapy can offer promising method in the local treatment of head and neck cancer.
