Clinicopathological significance of CD137L expression in laryngeal carcinoma.
- Author:
Xiaoming LI
1
;
Xiuying LU
;
Yinghui CHEN
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, 050082, China. xml_968@sohu.com
- Publication Type:Journal Article
- MeSH:
4-1BB Ligand;
metabolism;
Adult;
Aged;
Aged, 80 and over;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Female;
Humans;
Laryngeal Neoplasms;
metabolism;
pathology;
Male;
Middle Aged;
Neoplasm Staging;
Prognosis
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(4):149-151
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of CD137L in laryngeal carcinoma, and to analyze its clinicopathological significance.
METHOD:The expression of CD137L in 50 laryngeal carcinoma specimens and 9 normal laryngeal mucous tissues were detected by immunohistochemical staining.
RESULT:The positive CD137L staining were found in all 50 cases of laryngeal carcinomas (100%), while its staining were negative in normal laryngeal mucous. There was significant difference between two groups (P < 0.01). The positive ratio of CD137L staining had no relationship with the factors such as age, sex and tumor site, while it had significant correlation with the pathological stage, T stage and lymph node metastasis.
CONCLUSION:The expression of CD137L might play an important role in the development of laryngeal carcinomas.
