Research on apoptosis changes of tensor veli palatini in patients with obstructive sleep apnea-hypopnea syndrome.
- Author:
Hongxun GONG
1
;
Xianming CHEN
;
Xian ZHANG
;
Fengfang LIU
Author Information
1. Department of Otolaryngology Head and Neck Surgery, Fuzhou General Hospital of PLA Nanjing Military Region, Fuzhou, 350025, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Airway Resistance;
Case-Control Studies;
Humans;
Male;
Middle Aged;
Palatal Muscles;
metabolism;
pathology;
Proto-Oncogene Proteins c-bcl-2;
metabolism;
Sleep Apnea, Obstructive;
metabolism;
pathology;
Young Adult;
bcl-2-Associated X Protein;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(3):108-111
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore apoptosis changes of dilator muscles in the upper airway by detecting the expression of Bax, Bcl-2 in tensor veli palatini in patients with OSAHS.
METHOD:The expression of Bax and Bcl-2 were detected in tensor veli palatini in 30 cases with OSAHS and 10 cases chronic tonsillitis without OSAHS by immunohistochemistry and image analytical system, and the results were analyzed.
RESULT:(1) The expression levels of Bax in the OSAHS group increased significantly compared to control group (P < 0.05), but there were no significant differences of Bcl-2 expression between two groups, the ratio of Bax/Bcl-2 increased significantly (P < 0.05). (2) There were positive correlations between AHI and the expression levels of Bax (r = 0.697, P < 0.01) respectively in the test group.
CONCLUSION:The results indicate that apoptosis occurred in tensor veli palatini in patients with OS AHS, and the more severity of OSAHS, the more apoptosis.
