Expression and relationship of EBV LMP1, COX-2 and VEGF-C in nasopharyngeal carcinoma.
- Author:
Xiang YI
1
;
Anzhou TANG
;
Ying QIN
;
Wensheng WEN
;
Weimin ZHAO
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanjing, 530021, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Cyclooxygenase 2;
metabolism;
Female;
Humans;
Male;
Middle Aged;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
Neoplasm Staging;
Vascular Endothelial Growth Factor C;
metabolism;
Viral Matrix Proteins;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(3):126-128
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the expression of vascular endothelial growth factor C (VEGF-C), Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1), cyclooxygenase-2 (COX-2) in nasopharyngeal carcinoma (NPC).
METHOD:LMP1, COX-2 and VEGF-C were detects by immunohistochemical staining for 57 case NPC tissue.
RESULT:The positives rates of LMP1, COX-2 and VEGF-C detected by immunohistochemical staining were 49.1% (28/57), 75.4% (43/57) and 59.6% (34/57), respectively. The expression of LMP1, COX-2 and VEGF-C were correlated to each other in NPC (P < 0.05).
CONCLUSION:LMP1 and COX-2 may induce expression of VEGF-C directly or LMP1 induce expression of VEGF-C by induce COX-2 expression, may contribute to lymph metastasis and develop NPC.
