Expression and clinical significance of calcium-activated chloride channel and mucins in nasal mucosa with allergic rhinitis.
- Author:
Wenli WU
1
;
Hongtao ZHEN
;
Yonghua CUI
;
Hanqi CHU
;
Lifen WANG
Author Information
1. Department Otorhinolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Chloride Channels;
metabolism;
Female;
Humans;
Male;
Middle Aged;
Mucin 5AC;
metabolism;
Nasal Mucosa;
metabolism;
Rhinitis, Allergic, Perennial;
metabolism;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(5):193-199
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the role of human calcium-activated chloride channel 1 (hCLCA1) and mucin MUC5AC in allergic rhinitis.
METHOD:The expression of hCLCA1 and MUC5AC were determined by RT-PCR and immunohistochemical assay in nasal mucosa on 20 patients with allergic rhinitis and 7 normal persons.
RESULT:The expression of hCLCA1mRNA in allergic rhinitis group was positive, whereas in normal control group was absent (P<0.01). The expression of MUC5AC mRNA and MUC5AC protein in the allergic rhinitis group were higher than that in the control, respectively (both P<0.01). The increased expression of hCLCA1mRNA in allergic rhinitis group were well correlated with the expression of MUC5ACmRNA and MUC5AC protein and the correlation coefficients were 0.752 and 0.694(both P<0.05).
CONCLUSION:Upregulation of hCLCA1 mRNA expression may play a pivotal role in mucus overproduction in allergic rhinitis group. The inhibition of HCLCA1 expression may provide a new strategy for the treatment of allergic rhinitis.
