The study on the relationship between human papillomavirus infection and pathogenesis of nasal inverted papilloma and its malignant transformation.
- Author:
Zhenhua ZHONG
1
;
Aihui YAN
;
Feifei JIANG
;
Hongquan WEI
;
Xuejun JIANG
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, the First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Cell Transformation, Neoplastic;
pathology;
Female;
Humans;
Male;
Middle Aged;
Nose Neoplasms;
pathology;
virology;
Papilloma, Inverted;
pathology;
virology;
Papillomaviridae;
Papillomavirus Infections;
pathology;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(5):209-211
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between human papillomavirus (HPV) infection and pathogenesis of nasal inverted papilloma (NIP) and its malignant transformation.
METHOD:Fifty-seven cases of NIP were divided into 2 groups: benign group, squamous cell carcinoma (SCC) arising in NIP group (malignancy group). HPV-DNA types of 6, 11, 16, 18 were detected by polymerase chain reaction (PCR) in 57 cases of NIP. Thirty cases of nasal polyps were control.
RESULT:Total positive rate of HPV in NIP was 64.9% (37/57). The positive rate of benign group was 60% (27/45), all with single and low risk HPV11 type infection. The positive rate of malignancy group were was 83.3% (10/12), and the majority were HPV16 and HPV18. Five cases had double infection (4 with HPV16 and HPV 18, 1 with HPV11 and HPV18), four had single HPV16 infection, another one had single HPV11 infection. However, HPV-DNA was not detected in any cases of nasal polyps.
CONCLUSION:Infection of HPV-DNA has an important effect in pathogenesis of NIP. Meanwhile, there maybe a close relationship between high risk HPV16 type and HPV18 type and malignant transformation of NIP.
