Expression of BDNF mRNA in nasal mucosa with allergic rhinitis rat model.
- Author:
Feng TAO
1
;
Fengbing ZHANG
;
Zhichun HUANG
;
Baobin SUN
;
Xu FENG
Author Information
1. Department of Otorhinolaryngology, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Brain-Derived Neurotrophic Factor;
genetics;
metabolism;
Disease Models, Animal;
Nasal Mucosa;
metabolism;
RNA, Messenger;
genetics;
Rats;
Rats, Sprague-Dawley;
Rhinitis, Allergic, Perennial;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(5):224-226
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the role of brain-derived neurotrophic factor (BDNF) in allergic rhinitis of rat.
METHOD:Thirty SD rats free of disease were randomly divided into two groups. A model of allergic rhinitis rat was established by using ovalbumin intraperitoneal immunization and intranasal antigen challenge. The nasal mucosa from 18 out of 20 AR models as well as 10 normal controls were studied for expression of BDNF mRNA by reverse transcription-polymerase chain reaction (RT-PCR).
RESULT:BDNF/beta-actin ratio in AR models was significantly higher than control (0.49+/-0.07 vs 0.28+/-0.01, P<0.05).
CONCLUSION:BDNF played an important role in the development of allergic rhinitis of rat.
