Association of regulatory region of HLA-DPB1 with nasopharyngeal carcinoma in southern Chinese Hans.
- Author:
Pei WANG
1
;
Hua ZOU
;
Lin DING
;
Qiujian CHEN
;
Yiqing ZHENG
;
Yuping WU
;
Anlong XU
;
Yimin LIU
;
Yueping KONG
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, the Second Affiliated Hospital, Sun Yat-sen University, China.
- Publication Type:Journal Article
- MeSH:
Alleles;
Asian Continental Ancestry Group;
genetics;
Base Sequence;
Case-Control Studies;
Gene Frequency;
HLA-DP Antigens;
genetics;
HLA-DP beta-Chains;
Haplotypes;
Humans;
Molecular Sequence Data;
Nasopharyngeal Neoplasms;
genetics;
Polymorphism, Single Nucleotide
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(6):261-263
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To clarify the association between regulatory region of HLA-DPB1 (3'UTR) with Naso pharyngeal carcinoma in Guangdong Province Hans.
METHOD:The allelic types of HLA-DPB1-3'UTR were detected by sequence specific primer (SSP) in 104 patients with NPC and 105 control individuals from Guangdong Province Hans.
RESULT:The frequencies of allelic types B/B, haplotype B were higher in patients with NPC than those of the control individuals.
CONCLUSION:Positive association may exist between certain HLA-DPB1 alleles and NPC in Guangdong Province Hans.
