Expression of nuclear factor-kappa B p65 in hyperlipemia model of mice.
- Author:
Zhengde DU
1
;
Qingsong YU
;
Yi XIANG
Author Information
1. Department of Otolaryngology,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cochlea;
metabolism;
Disease Models, Animal;
Hyperlipidemias;
metabolism;
Mice;
Mice, Inbred Strains;
Transcription Factor RelA;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;24(7):289-292
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of nuclear factor kappa B p65 in hyperlipemia model of mice, and the relationship between hyperlipemia and deaf.
METHOD:Twenty mice were divided into two group. The hyperlipemia diet group was established in ten mice,and the normal diet group was served as normal control. Six weeks later, immunohistostaining was used to detected the express of NF-kappa B p65 in all mouse cochlear. ABR threshold was obtained from both normal group and hyperlipemia group.
RESULT:Immunoreactivity NF-kappa B p65 in mouse cochlea of hyperlipemia was localized in the organ of Corti, tectorial membrane, stria vascularis, spiral ligament, spiral ganglion and nerve fibers. The NF-kappa B p65 expression was markedly increased in mouse cochlea of hyperlipemia ABR threshold was significant difference between hyperlipemia group mice and control group mice (P < 0.01).
CONCLUSION:The expression of NF-kappa B p65 in mouse cochlea can be induced by hyperlipemia. And ABR threshold increased in hyperlipemia group mice. This shows that hyperlipidemia can damage acouesthesia of mice.
