Expressions of COX-2 and MMP-2 in nasopharyngeal carcinoma and the their relationship with lymph node metastasis.
- Author:
Dewei CUI
1
;
Xiangbao ZHANG
;
Yafeng FU
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China. cuidewei@163.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Case-Control Studies;
Cyclooxygenase 2;
metabolism;
Female;
Humans;
Lymph Nodes;
pathology;
Lymphatic Metastasis;
Male;
Matrix Metalloproteinase 2;
metabolism;
Middle Aged;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
Prognosis;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(15):692-694
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of cyclooxygenase-2 (COX-2) and matrix metalloproteinase-2 (MMP-2) in nasopharyngeal carcinoma (NPC) and their relationship with lymph node metastasis.
METHOD:The expression of COX-2 and MMP-2 in 86 NPC tissues and 30 normal nasopharyngeal tissues were evaluated by immunohistochemical analysis.
RESULT:The positive rate of COX-2 and MMP-2 in NPC tissue was 75.58% and 66.28% respectively, which was significantly higher than that in normal nasopharyngeal (P < 0.01). The expression of both COX-2 and MMP-2 were positively correlated with lymph node metastasis (P < 0.01). There was a positive correlation between the expression of COX-2 and MMP-2 (P < 0.01).
CONCLUSION:COX-2 and MMP-2 expression are increased in NPC, and they may cooperate in the course of lymph metastasis of NPC.
