Expression of angiopoietin-1,2 and its relationship with angiogenesis in laryngeal squamous cell carcinoma.
- Author:
Guang XU
1
;
Weihua LOU
;
Zhanwei SUN
;
Peng ZHANG
Author Information
1. Department of Otolaryngology, First Hospital of Zhengzhou University, Zhengzhou 450052, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Angiopoietin-1;
metabolism;
Angiopoietin-2;
metabolism;
Carcinoma, Squamous Cell;
blood supply;
metabolism;
pathology;
Female;
Humans;
Laryngeal Neoplasms;
blood supply;
metabolism;
pathology;
Male;
Microcirculation;
Middle Aged;
Neovascularization, Pathologic;
Vascular Endothelial Growth Factor A;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(17):772-776
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of Angiopoietin-1,2 in laryngeal squamous cell carcinoma (LSCC) and the relationship between Angiopoietin-1,2 expression and clinicopathologic parameters and microvessel density (MVD) marked by CD105, and also evaluate the significance of co-expression of Ang-2 and vascular endothelial cell growth factor (VEGF) in tumor angiogenesis.
METHOD:The expression of Ang-1,2 and VEGF in samples of tumor, para cancer and normal mucosa were detected by immunohistochemical method.
RESULT:The expression of Angiopoietin-1,2 were identified in LSCC, para cancer tissue and normal mucosa. The VEGF expression was only existed in LSCC. The expression of Ang-1,2 were significantly higher in LSCC than in para cancer tissue (P < 0.05) and normal mucosa (P < 0.01). In the clinicopathologic parameters, only the expression of Ang-2 was closely correlated with clinical stages and MVD (all P < 0.05). There was no significant correlation between the expression of Ang-1,2 and tumor differentiation degree (all P > 0.05). When the expression of Ang-2 and VEGF were both positive, the mean value of MVD was higher than others (P < 0.05).
CONCLUSION:These results suggest that overexpression of Ang-1,2 may play a very important role in the development of LSCC and are closely correlated with angiogenesis. Ang-2 promote angiogenesis when interacting with VEGF.
