Observation of ultrastructure and ECP expression in nasal polyps.
- Author:
Zhongfang XIA
1
;
Weijia KONG
;
Jianxin YUE
;
Yanjun WANG
;
Lisha WU
Author Information
1. Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Case-Control Studies;
Eosinophil Cationic Protein;
metabolism;
Eosinophils;
metabolism;
Female;
Humans;
Male;
Microscopy, Electron;
Middle Aged;
Nasal Mucosa;
metabolism;
pathology;
ultrastructure;
Nasal Polyps;
metabolism;
ultrastructure;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(17):787-797
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the ultrastructural feature and ECP expression in nasal polyps, and aim to explore its role in the pathogenesis of CRSwNP.
METHOD:5 CRSwNP, 5 CRS and 5 control patients underwent sinus surgery were gathered to detect its ultrastructure and expression of ECP by in situ hybridization and electron microscopy technique.
RESULT:Under electron microscopy, the eosinophilic cells in CRSwNP group increased, its membrane was intact but fold, the feature of pseudopodium, degranulation and cavitation were all found. The expression level of ECP mRNA was up-regulated.
CONCLUSION:The findings suggest that eosinophilic infiltrate and ECP cytologic inflammation reactions may involve in the pathogenesis of CRSwNP.
