Clinical significance of the expression of p53, p63 and p73 in nasal and paranasal sinus carcinoma.
- Author:
Tao ZHANG
1
;
Haiying JIA
;
Jiqun WANG
;
Yanchun SHAN
;
Sijin LUO
;
Zhi TANG
Author Information
1. Department of Otolaryngology, the First Affiliated Hospital of Ji'nan University, Guangzhou, 510630, China.
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
metabolism;
pathology;
DNA-Binding Proteins;
metabolism;
Female;
Humans;
Male;
Middle Aged;
Nose Neoplasms;
metabolism;
pathology;
Nuclear Proteins;
metabolism;
Paranasal Sinus Neoplasms;
metabolism;
parasitology;
Trans-Activators;
metabolism;
Transcription Factors;
Tumor Protein p73;
Tumor Suppressor Protein p53;
metabolism;
Tumor Suppressor Proteins;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(20):919-921
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the clinical significance of the expression of p53, p63 and p73 protein and the correlation of p53 and p63 in nasal and paranasal sinus carcinoma (NPSC).
METHOD:The immunohistochemical technique was used to detect the expression of p53, p63 and p73 in 67 cases of NPSC, para-cancer tissues and non-cancer tissues.
RESULT:The positive rate of p53 and p63 protein in NPSC was significantly higher than that in park cancer tissues and non-cancer tissues (P<0.01), and there were a positive correlation between the expression of p53 and p63 protein in NPSC (P<0.01). But the expression of p73 had no significant difference among NPSC, para-cancer tissues and non-cancer tissues (P>0.05).
CONCLUSION:There are positive correlation between p53 and p63 protein in NPSC, and they may play an important role in the tumorgenesis of NPSC. The p73 may not be associated with tumorgenesis of NPSC.
