Expression and clinical significance of insulin like growth factor-1 protein in nasopharyngeal carcinoma.
- Author:
Shucheng YIN
1
;
Xuhong ZHOU
;
Tao PENG
;
Jun LI
;
Xiaoqing JIANG
Author Information
1. Department of Otolaryngology, Zhongnan Hospital of Wuhan University,Wuhan, 430071, China. yinshucheng@sohu.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Apoptosis;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Cell Line, Tumor;
Female;
Humans;
Lymphatic Metastasis;
Male;
Middle Aged;
Nasopharyngeal Neoplasms;
metabolism;
pathology;
Receptor, IGF Type 1;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(19):874-877
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the expression of IGF-1R protein and its clinical signification in nasopharyngeal carcinoma.
METHOD:SP immunohistochemical staining was performed to detect the expression of IGF-1R in 63 cases of NPC and 21 inflammatory nasopharyngeal mucosa; and the expression of IGF-1R in three NPC cell lines and chronic nasopharyngitis tissues was examined by western blots.
RESULT:The positive rates of IGF-1R were 82.5% and 14.3% respectively in 63 cases of NPC and 21 inflammatory nasopharyngeal mucosa; it also showed stronger positive expression in Stage III-IV of NPC than that in stage I-II (P < 0 01); IGF-1R positive expression in cases of NPC with cervical lymph node metastasis was significantly higher than that of NPC without lymph node metastasis (P < 0.05); it more often appears in recurrent cases than in primary cases (P < 0.05); IGF-1R positive expression had a significantly stronger in patients whose survival time less than 5 years than that in patients whose survival time over 5 years (P < 0.01).
CONCLUSION:Over-expression of IGF-1R is related to poor differentiation of NPC, also may be linked with oncogenesis and development of NPC. The over-expression of IGF-1R may be one of a prognostic factors in NPC. The IGF-1R might be a potential therapeutic target in nasopharyngeal cancer.
