The significance of p63 expression in thyroid neoplasm.
- Author:
Minfei QIAN
1
;
Jiadong WANG
Author Information
1. Department of Otolaryngology Head and Neck Surgery, Renji Hospital, Shanghai Jiaotong University, Shanghai, 200001, China.
- Publication Type:Journal Article
- MeSH:
Adenocarcinoma, Follicular;
metabolism;
pathology;
Adenocarcinoma, Papillary;
metabolism;
pathology;
Biomarkers, Tumor;
Carcinoma, Medullary;
metabolism;
pathology;
Carcinoma, Papillary;
metabolism;
pathology;
Humans;
Neoplastic Stem Cells;
metabolism;
Thyroid Neoplasms;
metabolism;
pathology;
Trans-Activators;
metabolism;
Transcription Factors;
Tumor Suppressor Proteins;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(19):888-893
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the significance of p63 expression in thyroid carcinoma, thyroid papillary carcinoma, thyroid follicular carcinoma, squamous cell carcinoma and medullary thyroid carcinoma in order to find the possible causes of such thyroid-related diseases and if there is some kind of relation among them.
METHOD:The expression of p63 was examined in 10 thyroid carcinomas, 20 thyroid papillary carcinomas, 4 thyroid follicular carcinomas, 2 squamous cell carcinomas and 2 medullary thyroid carcinomas using direct immunofluorescence.
RESULT:It was shown that p63 expressed in all the thyroid-related diseases mentioned above. In squamous cell carcinoma, p63 has the highest expression and the expression of p63 in thyroid papillary carcinoma has no obvious relationship with the patients age, sex, the size and location of tumor and neoplasm metastasis.
CONCLUSION:The p63 masculine stem cells in thyroid could be one of the causes of some thyroid papillary carcinomas and thyroid follicular carcinomas. Thyroid papillary carcinoma, thyroid follicular carcinoma and squamous cell carcinoma may have similar origins.
