Expression change of Muscarinic receptor subunits in rat flocculus following unilateral labyrinthectomy.
- Author:
Yu ZOU
1
;
Weijia KONG
Author Information
1. Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cerebellum;
metabolism;
Functional Laterality;
Gene Expression;
Male;
Postoperative Period;
Rats;
Receptor, Muscarinic M1;
metabolism;
Receptor, Muscarinic M3;
metabolism;
Receptor, Muscarinic M5;
metabolism;
Vestibule, Labyrinth;
metabolism;
surgery
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(19):896-903
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the expression of Muscarinic receptor M1, M3, M5 subunits in rat flocculus following left unilateral labyrinthectomy (UL).
METHOD:The RT-PCR was used to observe the expression of Muscarinic receptor M1, M3, M5 subunits post-unilateral labyrinthectomy and investigate its effect on vestibular compensation.
RESULT:Muscarinic receptor M1, M3, M5 subunits were induced decrease in both side flocculus after unilateral labyrinthectomy. The expression was the least in the 1 d flocculus of following UL. The expression is rising from the 3-7 d flocculus of following UL. No difference was observed in the 7 d and sham operation flocculus following UL. No difference was observed in the ipsilateral and contralateral flocculus at any group.
CONCLUSION:Muscarinic receptor M1, M3, M5 subunits were induced decrease in the flocculus after unilateral labyrinthectomy. But the significance of the change of Muscarinic receptor M1, M3, M5 subunits in the vestibular compensation is still unknown.
