Expression of OX40 and Bcl-2 in allergic rhinitis.
- Author:
Jiandong ZHAO
1
;
Wei LI
;
Yanjun WANG
;
Xuemei CHEN
Author Information
1. Department of Otolaryngology, Second Affiliated Hospital, Shandong University, Jinan 270012, China. zhaojd.jack@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Biopsy;
Case-Control Studies;
Female;
Humans;
Middle Aged;
Nasal Mucosa;
metabolism;
pathology;
Proto-Oncogene Proteins c-bcl-2;
metabolism;
Receptors, OX40;
metabolism;
Rhinitis, Allergic, Perennial;
metabolism;
pathology;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(23):1057-1059
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the role of OX40 and Bcl-2 in allergic rhinitis(AR).
METHOD:Twenty-three subjects of allergic rhinitis as experimental group were collected and 20 subjects of deflection of nasal septum as control group. OX40 and Bcl-2 expression were examined in biopsy specimens of AR patients and nasal septum patients by immunohistochemistry respectively. The relationship between OX40 and Bcl-2 expression was analyzed.
RESULT:OX40 and Bcl-2 expression increased in the AR patients. There were positive staining not only in CD4+ T cells,but also in vascular endothelial cell, epithelial cell and glandular epithelium cell (P < 0.01). Compared with control group, the expression of OX40 (0.239 4 +/- 0.033 5) and Bcl-2 (0.237 3 +/- 0.042 1) were significantly higher than that in control group (P < 0.01). The OX40 expression was closely related to Bcl-2 expression (r = 0.869 0, P < 0.05).
CONCLUSION:The abnormal expression of costimulatory molecule OX40 is well evidenced in AR. Bcl-2 expression is likely mediated by OX40 signal pathway.
