Investigation on degeneration of outer hair cells in guinea pig.
- Author:
Xixun KANG
1
;
Weijia KONG
;
Wanrong LI
;
Xiaorong ZENG
;
Song ZHNAG
;
Changkai GUO
;
Xiang HUANG
Author Information
1. Department of Otolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Calcium;
Cells, Cultured;
Cochlea;
cytology;
pathology;
Culture Media;
Guinea Pigs;
Hair Cells, Auditory;
cytology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(23):1087-1089
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the degeneration mechanics of outer hair cells in guinea pig.
METHOD:The mechanics of outer hair cells isolated by enzyme were observed under inverted microscope for 6-8 h continuously.
RESULT:Over half of living outer hair cells could keep good conditions in 6 hours. During the degeneration there was always a longitudinal fold line from tip to base. Presence or absence of calcium, as well as lossing of stereociliary bundle, couldn't change the conditions of out hair cells.
CONCLUSION:Neither calcium nor stereociliary bundle is the decisive cause in keeping outer hair cells alive, and its degeneration may be basically related with something surrounding the cell.
