Molecular genetic analysis of SLC26A4 2168A > G mutations in sensorineural hearing loss with unknown reason in Henan province.
- Author:
Yunhua ZHU
1
;
Lingling NENG
;
Meisheng LI
;
Mingmin DONG
Author Information
1. Department of Otolaryngology, Shangqiu First People's Hospital, Shangqiu 450052, China.
- Publication Type:Journal Article
- MeSH:
Base Sequence;
China;
epidemiology;
Genetic Testing;
Hearing Loss, Sensorineural;
epidemiology;
genetics;
Humans;
Membrane Transport Proteins;
genetics;
Mutation;
Sulfate Transporters;
Vestibular Aqueduct
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2008;22(22):1026-1031
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To survey the etiology of sensorineural hearing loss with unknown reason and the incidence of the mutation of SLC26A4 2168A > G in Henan province.
METHOD:The evaluation of hearing loss, etiologic survey, the molecular genetic analysis and temporal bone CT examination for genes common to hereditary hearing disorders were performed in 95 hearing-impaired patients in Henan province.
RESULT:In the deafness group, the incidence of large vestibular aqueduct syndrome (LVAS) which correlates with SLC26A4 2168A > G is 6.32%. The incidence of the gene diagnosis conformed to the clinical one is 83.3%.
CONCLUSION:There is a high incidence of SLC26A4 2168 A > G mutation in sensorineural hearing loss with unknown reason. Molecular genetic screening for these mutations and genetic counseling are effective methods to prevent the occurrence of hereditary hearing loss.
