Research of bimingan granule on dendritic cell in allergic rhinitis mice.
- Author:
Jiyong WU
;
Daonan YAN
;
Hua'an MA
;
Yun ZHU
;
Shizhong ZHANG
;
Yao HU
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Differentiation;
drug effects;
Cells, Cultured;
Dendritic Cells;
drug effects;
immunology;
Drugs, Chinese Herbal;
pharmacology;
Mice;
Mice, Inbred C57BL;
Rhinitis, Allergic;
drug therapy;
immunology
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(13):983-985
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the mechanism.
METHOD:We isolate the mouse bone marrow cells and cultured with rGM-CSF and rIL-4 to stimulate bone marrow cells to transfer to immature dendritic cells. And then the immature dendritic cells were costimulated with ILPS and different concentrations of Bimingan Granule.
RESULT:MHC II, CD80, CD86 were detected by flow cytometer and TNF-alpha, IL-1beta, IL-6 and IL-10 were quantified by ELISA.
CONCLUSION:Our results showed that Bimingan Granule may significantly inhibit the differentiation of immature dendritic cells to mature dendritic cells.
