Progress in application of the combination of neural stem cells and Schwann cells for nerve repairing.
- Author:
Yu LI
;
Ziwei YU
- Publication Type:Journal Article
- MeSH:
Animals;
Cells, Cultured;
Humans;
Nerve Regeneration;
Neural Stem Cells;
Peripheral Nerve Injuries;
physiopathology;
surgery;
Schwann Cells
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(13):1006-1009
- CountryChina
- Language:Chinese
-
Abstract:
Neural stem cells (NSCs) and Schwann cells (SCs) both play an important role in the recovery and regeneration of peripheral nerve injury, which makes them become the focus in the field of nerve injury research. SCs provide a suitable microenvironment for the recovery and regeneration of injured peripheral nerve through secreting various cytokines and other related factors, and they can significantly promote the differentiation of NSCs into neurons. Recently with the development of microsurgical technique, using nerve conduits along with NSCs and SCs to bridge nerve stumps so as to repair peripheral nerve injury has now attracted increasing research interest. In this article, we focus on the effects and mechanisms of NSCs and SCs on peripheral nerve injury and regeneration process, and describe the future trend and potential clinical application of the technology combining both two cells and nerve conduits to repair peripheral nerve injury.
