Neurotrophins up-express in peripheral blood of allergic rhinitis patients and related to Th2 hypothesis.
- Author:
Hao WANG
;
Renhui CHEN
;
Yanqing ZHONG
;
Yiqun GENG
;
Ciyun XU
;
Weibiao KANG
;
Yulong LIN
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Brain-Derived Neurotrophic Factor;
blood;
Case-Control Studies;
Child;
Female;
Humans;
Interleukin-10;
blood;
Interleukin-4;
blood;
Interleukin-6;
blood;
Male;
Nerve Growth Factor;
blood;
Nerve Growth Factors;
blood;
genetics;
Neurotrophin 3;
blood;
RNA, Messenger;
genetics;
Rhinitis, Allergic;
blood;
immunology;
Th1-Th2 Balance;
Young Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(14):1024-1027
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the expression of NGF, BDNF, NT-3 mRNA in the peripheral blood of patients with allergic rhinitis (AR). And to analyze the correlation between NGF, BDNF, NT-3 mRNA expression and the epidsode of rhinitis through Th-2 Hypothesis.
METHOD:This study was a group controlled trial. The expression of NGF, BDNF and NT-3 mRNA were tested by real-time quantitative RT-PCR and the concentrations of IL-4, IL-6, IL-10 and INF-alpha were tested by ELISA.
RESULT:The expression of NGF, BDNF and NT-3 mRNA in AR patients were 2.44, 4.46 and 1.78 times the amount of those in the healthy adults, respectively. The increased expression of NT-3 correlated positively with the scores of visual analog scale of AR. The concentrations of IL-4, IL-6 and IL-10, which were 2198 +/- 472 pg/mL, 9407 +/- 703 pg/mL and 3917 +/- 323 pg/mL respectively, were higher than those in the healthy adults. The concentration of INF-alpha was 2198 +/- 472 pg/mL and less than the healthy adults. The increased expressions of NGF, NT-3 were positively related to the increase of IL-4, IL-6 and IL-10.
CONCLUSION:The expressions of NGF, BDNF and NT-3 mRNA in AR patients are higher than those in the healthy adults. NGF, BDNF and NT-3 may contribute to the pathogenesis of AR. Moreover, NGF and NT-3 may induce the episode of rhinitis through Th-2 Hypothesis.
