The expression and significance of chemokines eotaxin and RANTES in the rat model of allergic rhinitis.
- Author:
Cuiling TIAN
;
Xiaoping LEI
;
Minhong SHUI
;
Yanhong ZHANG
;
Qianwei JIA
;
Jing TU
;
Gang LIAN
;
Siquan TANG
- Publication Type:Journal Article
- MeSH:
Animals;
Chemokine CCL11;
metabolism;
Chemokine CCL5;
metabolism;
Disease Models, Animal;
Female;
Lung;
metabolism;
Nasal Mucosa;
metabolism;
Rats;
Rats, Sprague-Dawley;
Rhinitis, Allergic;
metabolism
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2014;28(14):1069-1071
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the expression and significance of Eotaxin and RANTES in the rat model of allergic rhinitis (AR).
METHOD:20 female SD rats in 6-7 weeks were randomly divided into control group and AR group (n = 10, respectively). AR rat model was made with ovalbumin stimulation. To detect pathological changes in mucosa and chemokine Eotaxin, RANTES in their nasal and lung tissues after execution.
RESULT:Compared with the control group, Lung EOS cell counted higher in AR group and the difference was significant (P < 0.01); the AR rats nasal mucosa and lung tissue of Eotaxin, RANTES expression was significantly increased (P < 0.01).
CONCLUSION:There exist high expression of Eotaxin, RANTES, infiltration of eosinophils in nasal and lung tissue of model rats with allergic rhinitis, inferring that the upper and lower respiratory tract inflammatory response has obvious consistency.
