Study on the influence of tumor-associated neutrophils on the biological characteristics of malignant tumors and its mechanism
10.3760/cma.j.issn.1006-9801.2019.04.017
- VernacularTitle:肿瘤相关中性粒细胞对恶性肿瘤生物学特性的影响及机制研究
- Author:
Pengyu SUN
1
;
Jingyu WANG
;
Yangang ZHANG
Author Information
1. 山西医科大学研究生学院
- Keywords:
Neoplasms;
Neutrophil;
Cell proliferation;
Tumor microenvironment
- From:
Cancer Research and Clinic
2019;31(4):285-288
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of malignant tumors is closely related to the tumor microenvironment. Tumor-associated neutrophils (TAN) are important inflammatory cells in the tumor microenvironment. Studies have confirmed that TAN plays an important role in tumor growth, invasion, metastasis, pathological angiogenesis, and immunity escapes. TAN can be activated as an anti-tumor N1 type and a tumor-promoting N2 type. This article reviews the biological characteristics of TAN and the role of TAN in the malignant tumors and its mechanism.
