Progress of B7-H6 molecule in malignant tumors
10.3760/cma.j.issn.1006-9801.2019.04.013
- VernacularTitle:B7-H6分子在恶性肿瘤中的研究进展
- Author:
Siyuan YANG
1
;
Jing WANG
;
Xiaoyan KE
Author Information
1. 北京大学第三医院血液科 100191
- Keywords:
Tumor escape;
Neoplasms;
Killer cells;
natural;
B7-H6
- From:
Cancer Research and Clinic
2019;31(4):272-275
- CountryChina
- Language:Chinese
-
Abstract:
B7-H6 has been discovered as a new member of the B7 family in recent years, it can specifically bind to the NKp30, an activated receptor of natural killer (NK) cells to mediate NK cells' tumor immunity killing effect. B7-H6 expression is upregulated in a wide variety of malignant tumor cells, but expression deficiency in normal tissue is detected. The intrinsic mechanism of B7-H6 regulation has been explored, and the treatment targeting B7-H6 has achieved a good effect in animal experiments, which shows a wide prospect of clinical application. This paper summarizes the latest progress of B7-H6 molecule in malignant tumors.
