Clinical characteristics and prognosis of patients with neuroendocrine tumors of the thymus: a study based on the Surveillance, Epidemiology, and End Results database
10.3760/cma.j.issn.1006-9801.2019.03.008
- VernacularTitle:基于监测、流行病学和结果数据库的胸腺神经内分泌肿瘤患者临床特征及预后分析
- Author:
Gehan XU
1
;
Huawei ZOU
Author Information
1. 中国医科大学第二临床学院
- Keywords:
Neuroendocrine tumors;
Thymus gland;
Prognosis;
Grade
- From:
Cancer Research and Clinic
2019;31(3):176-179
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical manifestations and potential prognostic factors of neuroendocrine tumors of the thymus (NETT).Methods The clinical data of 139 patients with pathologically confirmed NETT from the Surveillance,Epidemiology,and End Results (SEER) database in National Cancer Institute between January 2007 and December 2014 were retrospectively analyzed.Cox proportional hazard regression was used to assess the prognostic influencing factors of NETT.Results The median age at diagnosis of 139 patients with NETT was 59 years old,and age was (58±17) years old.There were 95 males and 44 females,and the ratio was 2.2 ∶ 1.The median overall survival time was 90 months.Univariate analysis showed that the tumor stage (P =0.001),the tumor grade (P =0.001) and the surgery (P =0.003) were associated with prognosis.Multivariate analysis showed that the tumor grade was the independent prognostic factor for the patients with NETT (HR:5.70;95％ CI 1.75-18.58;P =0.004).Conclusion NETT is a rare malignancy with tremendous aggressiveness.Tumor grade is an independent risk factor for the prognosis of the patients with NETT,and the prognosis of well-differentiated patients is better than that of poorly differentiated patients.
