Analysis of prognosis of pulmonary adenocarcinoma with a micropapillary pattern and its influencing factors
10.3760/cma.j.issn.1006-9801.2019.03.003
- VernacularTitle:伴微乳头结构肺腺癌患者预后及其影响因素分析
- Author:
Jian ZHANG
1
;
Wang JING
;
Bobo LI
;
Hongbo GUO
Author Information
1. 济南大学 山东省医学科学院医学与生命科学院临床医学系 250200
- Keywords:
Lung neoplasms;
Adenocarcinoma;
Micropapillary pattern;
Pathology,surgical;
Prognosis
- From:
Cancer Research and Clinic
2019;31(3):154-157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the prognostic influencing factors of pulmonary adenocarcinoma with a micropapillary pattern (MPPAC).Methods A total of 109 MPPAC patients who received surgical operation in Shandong Cancer Hospital Affiliated to Shandong University from August 2012 to August 2015 were retrospectively analyzed.The median survival time and the survival rate of 1-,3-and 5-year were calculated by using Kaplan-Meier method,log-rank test was used for single-factor analysis and Cox regression analysis was used for multiple-factor analysis.Results The median overall survival time of 109 MPPAC patients was 55.0 months (3-67 months).The overall survival rate of 1-,3-and 5-year was 89.0％,61.5％,48.6％,respectively.Single factor analysis showed that the gender (x2 =7.208,P =0.007),the tumor size (x2 =24.083,P ＜ 0.01),lymph node metastasis (x2 =23.068,P ＜ 0.01),vascular tumor thrombosis (x2 =16.411,P ＜ 0.01),visceral pleural infiltration (x2 =18.438,P ＜ 0.01) and multiple tumors (x2 =28.563,P ＜0.01) were associated with the overall survival of MPPAC patients.Multiple factor analysis showed that the tumor size (RR =1.629,95％ CI 1.145-2.317,P =0.007),lymph node metastasis (RR =1.680,95％ CI 1.161-2.430,P =0.006) and vascular tumor thrombosis (RR =2.867,95％ CI 1.286-6.392,P =0.010) were the independent prognosis factors for MPPAC patients.Conclusion The MPPAC patients have a poor prognosis.The tumor size,lymph node metastasis and vascular tumor thrombosis could influence the prognosis of MPPAC patients.
