Expression of ultraconserved gene sequence uc.454 in non-small cell lung cancer and its clinical significance
10.3760/cma.j.issn.1006-9801.2019.03.001
- VernacularTitle:超保守基因序列uc.454在非小细胞肺癌中的表达及其临床意义
- Author:
Jun ZHOU
1
;
Chenghai WANG
;
Yumin HUANG
;
Fengqin WU
;
Xiaoping OUYANG
;
Yali WANG
;
Lei WANG
Author Information
1. 扬州大学附属医院呼吸科 225009
- Keywords:
Carcinoma,non-small-cell lung;
Genes;
uc.454;
TNM stage;
Prognosis
- From:
Cancer Research and Clinic
2019;31(3):145-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of ultra-conserved gene sequence uc.454 in non-small cell lung cancer (NSCLC) tissues and its clinical significance.Methods Real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) was used to detect the expression level of uc.454 mRNA in 130 cases of NSCLC and adjacent normal tissues from Affiliated Hospital of Yangzhou University between January 2014 and December 2017,and its association with clinicopathological factors and prognosis of NSCLC patients was analyzed.Results The expression level of uc.454 mRNA in NSCLC tissues was lower than that in adjacent normal tissues (2.98 ±0.96 vs.13.95± 2.23,t =98.441,P ＜ 0.05),and its expression level was associated with tumor infiltration depth (x2 =7.823,P =0.040),TNM stage (x2 =20.719,P ＜ 0.01) and lymph node metastasis (x2 =24.142,P ＜ 0.01).The survival time of patients with low expression of uc.454 mRNA was shorter than that of patients with normal or high expression (26.9 months vs.43.7 months),and the difference was statistically significant (P ＜ 0.05).Conclusion The low expression of ultra-conserved gene sequence uc.454 mRNA is related to the occurrence,development and prognosis of NSCLC.
