Biological functions of alpha-fetoprotein in hepatocellular carcinoma
10.3760/cma.j.issn.1006-9801.2019.02.014
- VernacularTitle:肝癌发生过程中甲胎蛋白的生物学功能
- Author:
Haipeng FENG
1
;
Bo LIN
;
Mengsen LI
Author Information
1. 海南医学院海南省肿瘤发生与干预重点实验室
- Keywords:
Liver neoplasms;
Alpha-fetoproteins;
Apoptosis;
Immunosuppression;
Liver cancer stem cells
- From:
Cancer Research and Clinic
2019;31(2):130-134
- CountryChina
- Language:Chinese
-
Abstract:
With the in-depth study of alpha-fetoprotein (AFP) and lymphocyte immune regulation, tumor suppressor protein factor and stem cell factor, it is found that AFP is involved in tumorigenesis, growth, metastasis and maintenance of liver cancer cell stem cell function. AFP inhibits natural killer cell activity by inhibiting lymphatic system to protect the liver cancer cells from immune surveillance; AFP can also inhibit the activity of tumor suppressor genes such as caspase-3, pten, p53 and tumor suppressor proteins; AFP can promote the formation of liver cancer stem cells and maintains stability through activating the expressions of other cancer stem cells factors. This paper reviews the biological functions of AFP by regulating hepatocellular carcinoma cells to evade immune surveillance, inhibiting apoptosis and maintaining the generation of liver cancer stem cells.
