Progress of anti-tumor mechanisms of reovirus
10.3760/cma.j.issn.1006-9801.2019.02.013
- VernacularTitle:呼肠孤病毒抗肿瘤机制研究进展
- Author:
Ruimin CAI
1
;
Qiang FENG
;
Yi LI
;
Wenyang WANG
Author Information
1. 山东省泰安市中心医院检验科
- Keywords:
Neoplasms;
Oncolytic viruses;
Reovirus
- From:
Cancer Research and Clinic
2019;31(2):127-130
- CountryChina
- Language:Chinese
-
Abstract:
Oncolytic viruses have made great breakthroughs in cancer treatment, especially for reovirus, which can effectively induce the death of tumor cells without harming the normal tissues. More than 80％ tumor cells are sensitive to reovirus infection. Reovirus induces the apoptosis of tumor cells and exerts anti-tumor immunity to achieve anti-tumor activity, and the curative effect of combination therapy with reovirus and chemotherapeutic drugs exceeds the effect of monotherapy. Reovirus can exert anti-tumor effects through different mechanisms, which is of great significance for the new and effective treatment of tumors in the future.
