The application of serum HBV RNA detection in anti-HBV treatment
10.3760/cma.j.issn.1009-9158.2019.03.014
- VernacularTitle:血清HBV RNA检测在抗HBV治疗中的应用
- Author:
Shaoying GUO
1
;
Qishui OU
Author Information
1. 福建医科大学第一临床医学院
- Keywords:
Hepatitis B,chronic;
Hepatitis B virus;
RNA,viral;
DNA;
circular;
Nucleosides;
Interferon-alpha;
Polyethylene glycols
- From:
Chinese Journal of Laboratory Medicine
2019;42(3):219-223
- CountryChina
- Language:Chinese
-
Abstract:
The persistence of covalently closed circular DNA (cccDNA) in the nucleus of liver cells is a key factor that hinders the cure of chronic hepatitis B. However,it is difficult to eliminate cccDNA with existing anti-HBV therapy. Recent studies have found that serum HBV RNA may be a new indicator reflecting the activity of cccDNA in hepatocytes and evaluating the clinical efficacy of CHB patients . This article reviews recent advances in the properties,detection methods,and clinical significance of HBV RNA, particularly the application of antiviral therapy in CHB patients.
