Circulating non-coding RNAs as biomarkers in breast cancer diagnosis
10.3760/cma.j.issn.1009-9158.2019.01.013
- VernacularTitle:循环非编码RNA作为乳腺癌标志物的研究进展
- Author:
Guihua WANG
1
;
Jiang PU
;
Lei SHEN
;
Shaoqing JU
Author Information
1. 江苏省南通大学附属医院医学检验科 226001
- Keywords:
Breast neoplasms;
microRNAs;
RNA,long noncoding;
Biomarkers,tumor
- From:
Chinese Journal of Laboratory Medicine
2019;42(1):63-66
- CountryChina
- Language:Chinese
-
Abstract:
Non-coding RNAs (ncRNAs) are genomic transcripts that do not encode proteins.They are also closely associated with tumor initiation and progression,as they play regulatory roles in gene transcription,post-transcription,and translation.Moreover,ncRNAs may enter circulatory system in the form of microvesicles or exosomes,or in combination with protein.The circulating ncRNAs are stable and widely existed in body fluids such as blood and urine.Certain circulating ncRNAs are differentially expressed in tumors,suggesting that they have potential value as novel tumor biomarkers.This article briefly reviews the progress of circulating microRNA (miRNA),long non-coding RNA (lncRNA) and circular RNA (circRNA) as breast cancer biomarkers,and discusses the clinical value of circulating ncRNA as a novel biomarker for breast cancer diagnosis and prognosis.
