The function of OPG/RANKL/RANK system in tumor bone metastasis
10.3760/cma.j.issn.1009-9158.2019.01.004
- VernacularTitle:OPG/RANKL/RANK系统在肿瘤骨转移中的作用
- Author:
Yu SU
1
;
Xiaojun ZHOU
;
Tao HUANG
Author Information
1. 海南省人民医院检验科
- Keywords:
Neoplasm metastasis;
Bone neoplasms;
Osteoprotegerin;
RANK Ligand;
Receptor activator of nuclear factor-kappa B
- From:
Chinese Journal of Laboratory Medicine
2019;42(1):14-17
- CountryChina
- Language:Chinese
-
Abstract:
Tumor bone metastasis is one of the main causes of treatment failure in tumor.Since tumor bone metastasis is a complex process,the exact etiopathogenesis of tumor bone metastasis has not been clarified.Recent studies demonstrated that osteoprotegerin/receptor activator of NF-κB ligand/receptor activator of NF-κB (OPG/RANKL/RANK) system plays an important role during the development and progression of tumor bone metastasis.In this review,the research progress of OPG/RANKL/RANK system,including biological functions,the bone microenvironment regulation,the detection method,the diagnosis and treatment of tumor will be summerized.
