Correlation between obstructive sleep apnea syndrome and nonarteritic anterior ischemic optic neuropathy
10.3760/cma.j.issn.1005-1015.2019.03.006
- VernacularTitle:阻塞性睡眠呼吸暂停综合征与非动脉炎性前部缺血性视神经病变的相关性分析
- Author:
Luxi LI
1
;
Yanhui WANG
;
Jie YUAN
;
Zhao JIANG
;
Peng ZHANG
Author Information
1. 西安市第三医院眼科西北大学附属医院眼科 710018
- Keywords:
Sleep apnea,obstructive;
Optic neuropathy ischemic;
Correlation analysis
- From:
Chinese Journal of Ocular Fundus Diseases
2019;35(3):242-245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the correlation between obstructive sleep apnea syndrome (OSAS)and nonarteritic ischemic optic neuropathy (NAION).Methods It was a perspective study.A total of 41 consecutive patients with NAION (NAION group) and 41 age-and sex-matched physical examination subjects (control group) in Xi'an No.3 Hospital from December 2016 to December 2018 were enrolled in this study.The apnea hypopnea index (AHI,the number of sleep apneas per hour) was monitored using a polysomnography for patients in NAION group and control group.At the same time,the blood oxygen saturation was continuously recorded.The OSAS can be diagnosed if the AHI value was ≥ 5.OSAS severity was graded as mild:5≤AHI＜ 15;moderate:15≤AHI＜30;severe:AHI ≥30.The grading of OSAS severity between two groups was compared by Fisher's exact test.The AHI and minimum blood oxygen saturation were compared between NAION group and control group using the Mann-Whitney U test.Spearman correlation analysis was performed on the correlation between OSAS and NAION.Results Among the patients in the NAION group,31 patients (75.61％) were diagnosed with OSAS.Among them,6 patients (14.63％) were mild,9 patients (21.95％) were moderate,and 16 patients (39.03％) were severe.In the control group,19 patients (46.34％) were diagnosed with OSAS.Among them,10 patients (24.39％) were mild,5 patients (12.20％) were moderate,and 4 patients (9.75％) were severe.The difference of OSAS patients of mild,moderate and severe between two groups were statistically significant (Z=0.235,0.245,0.312;P=0.012,0.014,0.032).The average AHI of patients in the NAION group was 20.25 ± 7.74,and the mean minimum oxygen saturation at night was (87.38± 5.53)％.The average AHI of the control group was 18.67 ± 11.67,and the mean minimum oxygen saturation at night was (85.06+4.25)％.The differences of the mean AHI and mean minimum oxygen saturation between two groups were statistically significant (Z=1.124,2.317,P=0.003,0.020).There was a positive correlation between OSAS and NAION (Spearman correlation coefficient=0.229,P=0.030).Conclusion There is a positive correlation between OSAS and NAION.
