The changes of macular choroidal thickness in patients with mild to moderate Alzheimer's disease
10.3760/cma.j.issn.1005-1015.2019.03.004
- VernacularTitle:早中期阿尔茨海默病患者黄斑区脉络膜厚度变化临床观察
- Author:
Jing BAO
1
;
Zhigang LYU
;
Xiangxiang ZHANG
;
Danni YE
Author Information
1. 浙江省金华市中心医院眼科 321000
- Keywords:
Alzheimer's disease;
Tomography,optical coherence;
Choroidal thickness
- From:
Chinese Journal of Ocular Fundus Diseases
2019;35(3):231-234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To obverse the changes ofmacular choroidal thickness (CT) in patients with mild to moderate Alzheimer's disease (AD).Methods This was a case-control study.Twenty-one patients with mild to moderate AD confirmed by Neurology Department of Jinhua Central Hospital from November 2016 to June 2018 and 21 age-matched control subjects were concluded in the study.There was no significant difference in age (t=0.128),intraocular pressure (t=0.440) and axial length (t=1.202) between the two groups (P＞0.05).There was significant difference in mini-mental state examination score (t=8.608,P＜0.05).CT was measured by OCT with enhanced depth imaging technique in the subfoveal choroid,at 0.5 mm and 1.0 mm from the center of the fovea nasal (NCT0.5,1.0mm),temporal (TCT0.5,1.0mm),superior (SCT0.5,1.0mm),and inferior (ICT0.5,1.0mm).Independent-samples t test was used to compare the results obtained from these two groups.Results SFCT (t=2.431),NCT0.5,1.0 mm (t=3.341,2.640),TCT0.5,1.0 mm (t=3.340,2.899),SCT0.5.1.0 mm (t=3.576,3.751) and ICT0.5 (t=2.897,2.903) were significantly thinner in AD eyes than those in control eyes.Conclusion Compared with healthy subjects,patients with mild to moderate AD showed a significant reduction in CT.
