The prognosis in cases of hepatocellular carcinoma after hepatectomy: young patients versus older patients.
10.14701/kjhbps.2015.19.4.154
- Author:
Ji Soo LEE
1
;
Jong Man KIM
;
Seunghwan LEE
;
Jin Yong CHOI
;
Wontae CHO
;
Gyu Seoung CHOI
;
Jae Berm PARK
;
Choon Hyuck David KWON
;
Sung Joo KIM
;
Jae Won JOH
Author Information
1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. yjongman21@gmail.com
- Publication Type:Original Article
- Keywords:
Hepatocellular carcinoma;
Hepatectomy;
Young age;
Prognosis;
Survival
- MeSH:
Alkaline Phosphatase;
alpha-Fetoproteins;
Carcinoma, Hepatocellular*;
Causality;
Diagnosis;
Disease-Free Survival;
Hepatectomy*;
Hepatitis B virus;
Humans;
Incidence;
Indocyanine Green;
Liver;
Neoplasm Metastasis;
Portal Vein;
Prognosis*;
Recurrence;
Retrospective Studies;
Thrombosis;
Vitamin K;
Young Adult
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2015;19(4):154-160
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUNDS/AIMS: Hepatocellular carcinoma (HCC) is uncommon in young adults and the prognosis of these patients is still unclear. In this retrospective study, we compared the clinicopathological characteristics and outcomes of young patients with HCC with those of older patients with HCC. METHODS: We retrospectively reviewed the clinicopathological characteristics of a total of 1,124 patients with HCC who underwent hepatectomy at our institution between 2006 and 2010. Patients < or =40 years of age at the time of HCC diagnosis were classified in the younger group. RESULTS: One hundred and three patients (9.2%) were classified in the younger group. whereas, 1021 patients were classified in the older group. The incidences of hepatitis B virus infection, alpha-fetoprotein (AFP) levels, and indocyanine green retention test were all higher in younger patients than in older patients (p<0.05). Disease-free survival and overall survival were longer in older patients than in younger patients, without statistical significance. In younger patients, increased levels of protein induced by vitamin K antagonist-II (PIVKA-II) and alkaline phosphatase, portal vein tumor thrombosis, and intrahepatic metastasis were all predisposing factors for tumor recurrence after hepatectomy. CONCLUSIONS: Although the AFP levels were higher in younger patients with HCC than in older patients with HCC, disease-free survival and overall survival after liver resection were not significantly different between the two groups.
