The application of detecting BCAR1 (+)-circulating tumor cells in postoperative monitoring of early stage lung adenocarcinoma
10.3760/cma.j.issn.1001-4497.2019.03.009
- VernacularTitle:监测BCAR1阳性循环肿瘤细胞在早期肺腺癌术后随访中的应用
- Author:
Yunting CAI
1
;
Kai QIAN
;
Yonggeng FENG
;
Ruwen WANG
;
Jinghai ZHOU
;
Qunyou TAN
;
Bo DENG
Author Information
1. 中国人民解放军陆军军医大学大坪医院野战外科研究所胸外科
- Keywords:
Circulating tumor cells;
Breastcancer anti-oestrogen resistance protein 1;
Epithelialmesenchymal transition;
Lung adenocarcinoma
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2019;35(3):163-166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance regarding monitoring circulating tumor cells in early stage lung adenocarcinoma.Methods From November 2015 to January 2018,48 patients with stage Ⅰ lung adenocarcinoma were included in the study.BCAR1 expression in CTCs in peripheral blood were detected by using CanPatrolTM and RNA in situ hybridization detection.Results Among the 48 cases,CTCs and BCAR1 (+)-CTCs were detected in 41 cases(85.4％) and 30 cases(62.5％),respectively.Number of BCAR1 (+)-CTCs seemed to be significantly positively related to that of CTCs.BCAR1 (+)-CTCs were more likely to appear in the M-CTCS and E&M-CTCS.BCAR1 (+)-CTCs remarkably increased in three relapsed cases.Furthermore,there were 19 stable cases who had postoperative CTCs data:(1) in 12 patients,either CTCs or BCAR1 (+)-CTCs were significantly reduced or remained stable;(2) in 7 cases,CTCs increased,but BCAR1 (+)-CTCs remained stable in 2 cases,reduced in 1 case,and the other 4 cases underwent close follow-up.Conclusion Evaluation of BCAR1 (+)-CTCs possibly can be contributive to prediction of early lung adenocarcinoma recurrence or metastasis.
