Progress in lactic acid-mediated maintenance of healthy vaginal microecology
10.3760/cma.j.issn.0254-5101.2019.04.011
- VernacularTitle:乳酸维持正常阴道微生态的研究进展
- Author:
Mengting DONG
1
;
Xingshuo LI
;
Chen WANG
;
Wenyan TIAN
;
Fengxia XUE
Author Information
1. 天津医科大学总医院妇产科 300052
- Keywords:
Lactobacillus;
Lactic acid;
Pathogen;
Immunomodulator;
Vaginal microecology
- From:
Chinese Journal of Microbiology and Immunology
2019;39(4):311-315
- CountryChina
- Language:Chinese
-
Abstract:
Lactic acid is the main substance produced by Lactobacillus and plays an important role in maintaining a healthy vaginal microecology. Recent studies indicates that both L- and D-chiral isomers of lactic acid can be protonated and destroy the cell membranes of pathogens, thereby inhibiting bacterial vagi-nosis- and aerobic vaginitis-related pathogens. Lactic acid also can inhibit the pathogens of sexually transmit-ted diseases such as Chlamydia trachomatis and human immunodeficiency virus. Moreover, lactic acid acts as an immunomodulator to inhibit the inflammatory responses caused by pathogenic microorganisms and as an epigenetic regulator regulating gene expression in vaginal epithelial cells. In this paper, we reviewed the pro-gress in lactic acid-mediated maintenance of a healthy vaginal microbiology in recent years for providing ref-erence for further research.
