Advances in mechanism of macrophage pyroptosis in Mycobacterium tuberculosis infection
10.3760/cma.j.issn.0254-5101.2019.03.014
- VernacularTitle:巨噬细胞焦亡在结核分枝杆菌感染中作用机制的研究进展
- Author:
Haotian CHEN
1
;
Yurong FU
;
Zhengjun YI
Author Information
1. 潍坊医学院医学检验学系
- Keywords:
Pyroptosis;
Infectious diseases;
Caspase;
Mycobacterium tuberculosis;
Inflammasome
- From:
Chinese Journal of Microbiology and Immunology
2019;39(3):232-236
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is an inflammatory programmed cell death dependent on caspase, and partic-ipates in the development of infectious diseases. Mycobacterium tuberculosis can reside in macrophages, and therefore Mycobacterium tuberculosis infection is closely related to the pyroptosis of macrophages. This review reviewed and discussed the molecular mechanism of interactions between Mycobacterium tuberculosis and macrophage inflammasomes. It is helpful to further understand the occurrence and development of tuberculo-sis and provide new ideas for the prevention and control of Mycobacterium tuberculosis infection with the in-depth study of the mechanism of macrophage pyroptosis.
