Research progress in oxidative stress induced by antibiotics in bacteria
10.3760/cma.j.issn.0254-5101.2019.02.014
- VernacularTitle:细菌对抗菌药物产生氧化应激的研究进展
- Author:
Jiajie ZHANG
1
;
Shanliang YE
;
Wei YU
Author Information
1. 浙江省人民医院 杭州医学院附属人民医院感染病科 310014
- Keywords:
ROS;
Oxidative stress;
Antioxidant defense;
Transcriptional regulation
- From:
Chinese Journal of Microbiology and Immunology
2019;39(2):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Antibiotics can not only combine with specific targets, but also induce a cascade of re-active oxygen species ( ROS) in bacteria. Antioxidant defense system plays an important role in scavenging ROS and repairing injury against oxidative stress. However, the mechanism of ROS accumulation in bacteria and the action of ROS are very complicated. Therefore, this paper reviewed the mechanisms of bacterial re-sponding to oxidative stress in the existence of antibiotics. In addition, we analyzed the main problems lying in the current study and the issues needing further consideration.
